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defined Persistent Atrioventricular Canal

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The basic defect in this cardiac anomaly is a failure of fusion of the su­perior and inferior endocardial cush­ions. This malformation is seen in about 20% of the cases of Down syn­drome; otherwise it is relatively un­common cardiac anomaly. The failure of fusion of the endocardial cushions leads to a variety of secondary car­diac defects which include: (i) ASD consisting of osteum primum defect, (ii) membranous variety of VSD and (iii) malformations of the atrioventricular valves.
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